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Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg
  • Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg

Millipore/MAB5406 | Anti-GAD67 Antibody, clone 1G10.2/MAB5406/100 µg

價格: ￥4440.00 市場價: 7400.00
貨號: MAB5406
品牌: Millipore
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    • Description
      CatalogueNumberMAB5406
      ReplacesAB5992;AB5862P
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-GAD67Antibody,clone1G10.2
      AlternateNames
      • GlutamateDecarboxylase67kDaIsoform
      • GlutamateDecarboxylase1
      • Glutamicaciddecarboxylase1
      BackgroundInformationGutamicaciddecarboxylase(GAD;E.C.4.1.1.15)istheenzymeresponsIBLefortheconversionofglutamicacidtogamma-aminobutyricacid(GABA),themajorinhibitorytransmitterinhigherbrainregions,andputativeparacrinehormoneinpancreaticislets.TwomolecularformsofGAD(65kDaand67kDa,64%aaidentitybetweenforms)arehighlyconservedandbothformsareexpressedintheCNS,pancreaticisletcells,testis,oviductandovary.Theisoformsareregionallydistributedcytoplasmicallyinthebrainsofratsandmice(Sheikh,1999).GAD65isanamphiphilic,membrane-anchoredprotein(585a.a.),encodedonhumanchromosome10,andisresponsibleforvesicularGABAproduction.GAD67iscytoplasmic(594a.a.),encodedonchromosome2,andseemstoberesponsibleforsignificantcytoplasmicGABAproduction.GADexpressionchangesduringneuraldevelopmentinratspinalcord.GAD65isexpressedtransientlyincommissuralaxonsaroundE13butisdownregulatedthenextdaywhileGAD67expressionincreasesmostlyinthesomataofthoseneurons(Phelps,1999).Inmatureratpancreas,GAD65andGAD67appeartobedifferentiallylocalized,GAD65primarilyininsulin-containingbetacellsandGAD67inglucagon-containing(A)cells(Li,1995).GAD67expressionseemstobeparticularlyplasticandcanchangeinresponsetoexperimentalmanipulation(forexampleneuronalstimulationortransection)ordiseaseprogressionandemergentdisorderslikeschizophrenia(Volk,2000).ColocalizationofthetwoGADisoformsalsoshowschangesinGAD65/GAD67distributionscorrelatedwithcertaindiseasestatessuchasIDDMandSMS.
      ProductInformation
      FormatPurified
      Control
      • SKNSHcelllysate(humanneuroblastoma),mousecerebralcortex.
      PresentationPurifiedmousemonoclonalIgG2ainbuffercontaining0.1%sodiumazide
      StorageandShippingInformation
      StorageConditionsStablefor6monthsat2-8oCinundilutedaliquotsfromdateofreceipt.
      Applications
      ApplicationThisAnti-GADAntibody,clone1G10.2isvalidatedforuseinIH,IH(P),WBforthedetectionofGAD67.ThisAntiGADantibodyhasmorethan75productcitations.
      KeyApplications
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesWesternBlot:A1:5,000-1:10,000dilutionwasusedonapreviouslotusingECLonratandmousebrainlysate.

      Immunohistochemistryon4%paraformaldehydefixedmouseandrattissue:1:1,000-1:5,000.Theantibodyhasalsoworkedwellonhumantissuefixedfor10minutesin4%PFAat4°Cor100%ethanolat+20°Cor100%acetoneat-20°Catdilutionsof1:2,500-1:5,000.
      ApolyclonaltoGAD67isalsoavailableasAB5992.

      Optimalworkingdilutionsmustbedeterminedbyenduser.
      BIOLOGicalInformation
      ImmunogenRecombinantGAD67protein
      Clone1G10.2
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificityReactswiththe67kDaisoformofGlutamateDecarboxylase(GAD67)ofrat,mouseandhumanorigins,otherspeciesnotyettested.NodetectablecrossreactivitywithGAD65byWesternblotonratbrainlysatewhencomparedtoblotprobedwithAB1511thatreactswithbothGAD65&GAD67.
      IsotypeIgG2a
      SpeciesReactivity
      • Human
      • Rat
      • Mouse
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesoneofseveralformsofglutamicaciddecarboxylase,identifiedasamajorautoantigenininsulin-dependentdiabetes.Theenzymeencodedisresponsibleforcatalyzingtheproductionofgamma-aminobutyricacidfromL-glutamicacid.ApathogenicroleforthisenzymehasbeenidentifiedinthehumanpancreassinceithasbeenidentifiedasanautoantigenandanautoreactiveTcelltargetininsulin-dependentdiabetes.Thisgenemayalsoplayaroleinthestiffmansyndrome.Deficiencyinthisenzymehasbeenshowntoleadtopyridoxinedependencywithseizures.Alternativesplicingofthisgeneresultsintwoproducts,thepredominant67-kDformandaless-frequent25-kDform.
      GeneSymbol
      • GAD1
      • SCP
      • GAD-67
      • FLJ45882
      • GAD67
      • GAD
      • EC4.1.1.15
      PurificationMethodProteinAPurfied
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q99259#CatalyzestheproductionofGABA.
      COFACTOR:Pyridoxalphosphate.
      SIZE:594aminoacids;66897Da
      SUBUNIT:Homodimer.
      TISSUESPECIFICITY:GAD67isexpressedintheCNS,pancreaticisletcells,testis,oviductandovary.
      DISEASE:SwissProt:Q99259#DefectsinGAD1arethecauseofautosomalrecessivesymmetricspasticcerebralpalsy(SCP)[MIM:603513].Cerebralpalsy(CP)isanheterogeneousgroupofneurologicaldisordersofmovementand/orposture,withanestimatedincidenceof1in250to1"000livebirths,makingCPonethecommonestcongenitaldisABIlities.Non-progressiveformsofsymmetrical,spasticCPhavebeenidentified,whichshowaMendelianautosomalrecessivepatternofinheritance.Patientspresentdevelopmentaldelay,mentalretardationandsometimesepilepsyaspartofthephenotype.
      SIMILARITY:SwissProt:Q99259##BelongstothegroupIIdecarboxylasefamily.
      MolecularWeight67kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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