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Millipore/MABN50A4 | Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor?488 Conjugate | MABN50A4/MABN50A4/100 µL
  • Millipore/MABN50A4 | Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor?488 Conjugate | MABN50A4/MABN50A4/100 µL

Millipore/MABN50A4 | Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor?488 Conjugate | MABN50A4/MABN50A4/100 µL

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貨號: MABN50A4
品牌: Millipore
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    • Description
      Catalogue NumberMABN50A4
      DescriptionAnti-Olig2 Antibody, clone 211F1.1, Alexa Fluor?488 Conjugate | MABN50A4
      Alternate Names
      • Oligodendrocyte transcription factor 2
      • Oligo2
      • Class B basic helix-loop-helix protein 1
      • bHLHb1
      • Class E basic helix-loop-helix protein 19
      • bHLHe19
      • Protein kinase C-binding protein 2
      • Protein kinase C-binding protein RACK17
      Background InformationOligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.
      Product Information
      FormatAlexaFluor?488
      Control
      • Rat oligodendrocyte precursor cells
      PresentationPurified mouse monoclonal IgG2a conjugated to Alexa Fluor? 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Applications
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenRecombinant protein corresponding to human Olig2.
      Clone211F1.1
      HostMouse
      IsotypeIgG2a
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteDemonstrated to react with mouse and rat. Predicted to react with human based on 100% sequence homology
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008].
      Gene Symbol
      • OLIG2
      • BHLHB1
      • BHLHE19
      • PRKCBP2
      • RACK17
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).

      SIZE: 323 amino acids; 32385 Da

      SUBUNIT: Interacts with NKX2-2 (By similarity).

      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).

      TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

      DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity).DISEASE:SwissProt: Q13516 # A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

      SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
      Molecular WeightThe unconjugated parent antibody (Cat. No. MABN50) has an observed molecular weight at ~37 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Materials Information
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