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Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB25274
  • Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB25274

Abnova/AKT1 (phospho S473) polyclonal antibody/1kit/PAB25274

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貨號(hào): PAB25274
品牌: Abnova
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  • 詳情
  • 使用說(shuō)明
  • 常見(jiàn)問(wèn)題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1.
      • Immunogen:
      • Synthetic phosphopeptide corresponding to residues surrounding S473 of human AKT1.
      • Sequence:
      • Q-F-Sp-Y-S
      • Host:
      • Rabbit
      • Theoretical MW (kDa):
      • 60
      • Reactivity:
      • Human, Mouse, Rat
      • Form:
      • Liquid
      • Purification:
      • Affinity chromatography
      • Concentration:
      • 1 mg/mL
      • Recommend Usage:
      • Immunohistochemistry (1:50-1:100)Western Blot (1:500-1:1000)The optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
      • Storage Instruction:
      • Store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • Western blot analysis of extracts from HeLa cells untreated or treated with heat shock using AKT1 (phospho S473) polyclonal antibody (Cat # PAB25274).
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AKT1 (phospho S473) polyclonal antibody (Cat # PAB25274).
      • Application Image
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • enlarge
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 207
      • Protein Accession#:
      • P31749
      • Gene Name:
      • AKT1
      • Gene Alias:
      • AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA
      • Gene Description:
      • v-akt murine thymoma viral oncogene homolog 1
      • Omim ID:
      • 164730, 181500
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
      • Other Designations:
      • RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase alpha
      • Interactome
      • Interactome
      • Gene Pathway
      • Acute myeloid leukemia
      • Adipocytokine signaling pathway
      • Apoptosis
      • B cell receptor signaling pathway
      • Chemokine signaling pathway
      • Chronic myeloid leukemia
      • Colorectal cancer
      • Endometrial cancer
      • ErbB signaling pathway
      • Fc epsilon RI signaling pathway
      • Fc gamma R-mediated phagocytosis
      • Focal adhesion
      • Glioma
      • Insulin signaling pathway
      • Jak-STAT signaling pathway
      • MAPK signaling pathway
      • Melanoma
      • mTOR signaling pathway
      • Neurotrophin signaling pathway
      • Non-small cell lung cancer
      • Pancreatic cancer
      • Pathways in cancer
      • Prostate cancer
      • Renal cell carcinoma
      • Small cell lung cancer
      • T cell receptor signaling pathway
      • Tight junction
      • Toll-like receptor signaling pathway
      • VEGF signaling pathway
      • Related Disease
      • Adenocarcinoma
      • Adenocarcinoma, Papillary
      • Alzheimer Disease
      • Alzheimer disease
      • Amphetamine-Related Disorders
      • Atherosclerosis
      • Basal Ganglia Diseases
      • Bipolar Disorder
      • Breast Neoplasms
      • Calcinosis
      • Carcinoma
      • Carcinoma, Non-Small-Cell Lung
      • Carcinoma, Papillary
      • Carcinoma, Papillary, Follicular
      • Cardiovascular Diseases
      • Cognition
      • Colonic Neoplasms
      • Colorectal Neoplasms
      • Coronary Artery Disease
          • ... see more
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