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Abnova/CASP3 polyclonal antibody/1kit/PAB29334
  • Abnova/CASP3 polyclonal antibody/1kit/PAB29334

Abnova/CASP3 polyclonal antibody/1kit/PAB29334

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貨號: PAB29334
品牌: Abnova
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  • 詳情
  • 使用說明
  • 常見問題
      • Specification
      • Gene Info
      • Interactome
      • Pathway
      • Disease
      • Related Products
      • List All
      • Specification
      • Product Description:
      • Rabbit polyclonal antibody raised against recombinant human CASP3.
      • Immunogen:
      • Recombinant protein corresponding to amino acids of human CASP3.
      • Sequence:
      • HGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDL
      • Host:
      • Rabbit
      • Reactivity:
      • Human, Mouse, Rat
      • Form:
      • Liquid
      • Purification:
      • Antigen affinity purification
      • Isotype:
      • IgG
      • Recommend Usage:
      • Immunohistochemistry (1:500-1:1000)Western Blot (1:100-1:250)Immunofluorescence (1-4 ug/mL)The optimal working dilution should be determined by the end user.
      • Storage Buffer:
      • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
      • Storage Instruction:
      • Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
      • Note:
      • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
      • Datasheet:
      • PDF DownloadDownload
      • Applications
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • Western blot analysis of Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells); Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) with CASP3 polyclonal antibody (Cat# PAB29334) at 1:100-1:250 dilution.
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemical staining of human bone marrow with CASP3 polyclonal antibody (Cat# PAB29334) shows strong cytoplasmic positivity in bone marrow poietic cells at 1:500-1:1000 dilution.
      • Immunofluorescence
      • Immunofluorescence
      • Immunofluorescent staining of human cell line U-251 MG with CASP3 polyclonal antibody (Cat# PAB29334) under 1-4 ug/mL working concentration shows positivity in mitochondria and nucleus but excluded from the nucleoli.
      • Application Image
      • Western Blot (Cell lysate)
      • Western Blot (Cell lysate)
      • enlarge
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
      • enlarge
      • Immunofluorescence
      • Immunofluorescence
      • enlarge
      • Gene Information
      • Entrez GeneID:
      • 836
      • Protein Accession#:
      • A8MVM1
      • Gene Name:
      • CASP3
      • Gene Alias:
      • CPP32,CPP32B,SCA-1
      • Gene Description:
      • caspase 3, apoptosis-related cysteine peptidase
      • Omim ID:
      • 600636
      • Gene Ontology:
      • Hyperlink
      • Gene Summary:
      • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer"s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
      • Other Designations:
      • OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related cysteine protease,cysteine protease CPP32,procaspase3
      • Interactome
      • Interactome
      • Gene Pathway
      • Alzheimer"s disease
      • Amyotrophic lateral sclerosis (ALS)
      • Apoptosis
      • Colorectal cancer
      • Epithelial cell signaling in Helicobacter pylori infection
      • Huntington"s disease
      • MAPK signaling pathway
      • Natural killer cell mediated cytotoxicity
      • p53 signaling pathway
      • Parkinson"s disease
      • Pathways in cancer
      • Related Disease
      • Adenocarcinoma
      • Attention Deficit Disorder with Hyperactivity
      • Autistic Disorder
      • Carcinoma, Large Cell
      • Carcinoma, Non-Small-Cell Lung
      • Carcinoma, Small Cell
      • Carcinoma, Squamous Cell
      • Cardiovascular Diseases
      • Clubfoot
      • Colorectal Neoplasms
      • Diabetes Mellitus, Type 2
      • Diabetic Nephropathies
      • Disease Progression
      • Edema
      • Endometrial Neoplasms
      • Esophageal Neoplasms
      • Gastrointestinal Stromal Tumors
      • Genetic Predisposition to Disease
      • Head and Neck Neoplasms
          • ... see more
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